Researchers Develop Potent Compound Against Pancreatic Cancer


According to Cambridge researchers, their therapy wipes out solid tumors in mice in under one week.

Investigators from Cancer Research UK Cambridge Institute are working on a new therapy, known a AMD3100 or Plerixafor, saying that it can wipe out tumors in just six days, something never seen before in the lab against this type of cancer.

The therapy works by destroying a thick wall of chemokine protein around the cancerous cells which normally prevents the body's own T-cells from attacking the tumor.

"By enabling the body to use its own defenses to attack cancer, this approach has the potential to greatly improve treatment of solid tumors," said research leader Dr Douglas Fearon to the UK's Metro. "That is not just restricted to pancreatic cancer but would be effective in many forms, including ovarian and lung cancer, because they react similarly."

Pancreatic cancer is one of the deadliest cancers known to medicine. It is rarely found earlier than stage IV and has a 2-year relative survival rate of about three percent.

The team hopes that Human trials can begin in 2014 at Addenbrooke’s Hospital in Cambridge. It's possible the therapy, if safe and effective, could be available on the market within ten years.

Source: Metro UK


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