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Anthracycline possibly unnecessary in endometrial cancer treatment

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An abstract of interim results from an ongoing study presented at the meeting of the Society of Gynecologic Oncology has demonstrated that patients with advanced or recurrent endometrial cancer may be able to receive a regimen that is less toxic but equally as effective as the current standard of care.

Currently, these patients receive a three-drug chemotherapy regimen of paclitaxel, doxorubicin, and cisplatin (TAP), a regimen established by the Gynecologic Oncology Group 177 trial from 2004. However, the addition of the anthracycline doxorubicin has--expectedly--created toxicity problems.

Thus the Gynecologic Oncology Group launched the 209 trial, pitting TAP against the paclitaxel-carboplatin (TC) combination in a group of 1,300 women. What they found is that both regimens are associated with the same median progression-free survival (14 months) and that median overall survival was almost the same as well.

The TC group also experienced less toxicity and adverse events. Arguably, with the removal of the anthracycline, they should also endure fewer cardiopulmonary side effects down the road.

Source: MedPage Today

 

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